Clinical trials in Brno – page 5

390 clinical trials in Brno, Czechia across 1 research site. Every trial is listed in the EU Clinical Trials Register and updated daily.

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390 trials in Brno

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Chronic lymphocytic leukaemia recurrent+1

Recruiting

Registered drugNo placebo

A study of acalabrutinib and venetoclax for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma who have relapsed after initial treatment

Registered drugNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Acalabrutinib
Sponsor:AstraZeneca AB

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B-cell small lymphocytic lymphoma

Recruiting

Registered drugNo placebo

A study comparing BGB-11417 and zanubrutinib with venetoclax and acalabrutinib for patients with previously untreated chronic lymphocytic leukemia

Registered drugNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Acalabrutinib
Sponsor:BeOne Medicines I GmbH

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Hereditary haemochromatosis

Recruiting

Investigational

A study to evaluate the effectiveness and safety of vamifeport in adults with hereditary hemochromatosis

Investigational

Czechia

Participants:18–64 years · 65+ years
Substances:VAMIFEPORT TRIHYDROCHLORIDE
Sponsor:CSL Behring LLC

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Efficacy and safety of gadopiclenol versus gadoteric acid‑enhanced MRA in adult patients with suspected vascular disease

Recruiting

Registered drugNo placebo

Efficacy and safety of gadopiclenol versus gadoteric acid‑enhanced MRA in adult patients with suspected vascular disease

Registered drugNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Gadoteric Acid

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Juvenile idiopathic arthritis

Recruiting

Registered drugNo placebo

A study to evaluate the safety and effectiveness of filgotinib in children and adolescents aged 8 to 17 years with polyarticular juvenile idiopathic arthritis

Registered drugNo placebo

Czechia

Participants:0–17 years
Substances:Filgotinib
Sponsor:Alfasigma S.p.A.

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Acute lymphocytic leukaemia

Recruiting

Registered drugNo placebo

Study of Blinatumomab and a drug combination for older adults with newly diagnosed Philadelphia-negative B-cell precursor Acute Lymphoblastic Leukemia

Registered drugNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Asparaginase
Sponsor:Amgen Inc.

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Non-small cell lung cancer

Recruiting

Registered drugNo placebo

Comparing Sotorasib and Pembrolizumab with chemotherapy for patients with advanced non-small cell lung cancer and a KRAS G12C mutation

Registered drugNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Calcium Folinate
Sponsor:Amgen Inc.

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Squamous cell carcinoma of lung+4

Recruiting

Registered drug

A study of PF-08634404 and a drug combination in adults with advanced or metastatic non-small cell lung cancer

Registered drug

Czechia

Participants:18–64 years · 65+ years
Substances:Carboplatin
Sponsor:Pfizer Inc.

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Obstructive sleep apnoea syndrome

Recruiting

Investigational

Study of Maridebart Cafraglutide for Adults with Obstructive Sleep Apnea and Overweight or Obesity Who Use Positive Airway Pressure Therapy

Investigational

Czechia

Participants:18–64 years · 65+ years
Substances:Maridebart Cafraglutide
Sponsor:Amgen Inc.

Contact Research Centre

Acute myeloid leukaemia

Recruiting

Registered drug

Study of Ziftomenib with drug combinations for adults with newly diagnosed acute myeloid leukemia with NPM1 or KMT2A genetic changes

Registered drug

Czechia

Participants:18–64 years · 65+ years
Substances:Azacitidine
Sponsor:Kura Oncology Inc.

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Obstructive sleep apnoea syndrome

Recruiting

InvestigationalNo placebo

A Phase 3 Randomized, Double-blind,Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants with Obstructive Sleep Apnea not on Positive Airway Pressure Therapy and Living with Overweight or Obesity (MARITIME-OSA-2)

InvestigationalNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Maridebart Cafraglutide
Sponsor:Amgen Inc.

Contact Research Centre

Hepatitis D

Recruiting

Registered drugNo placebo

A study comparing brelovitug to bulevirtide for treating chronic hepatitis delta infection in patients currently receiving bulevirtide

Registered drugNo placebo

Czechia

Participants:18–64 years · 65+ years
Substances:Bjt-778
Sponsor:Mirum Pharmaceuticals Inc.

Contact Research Centre

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Clinical research in Brno

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01 Oncology Research

Innovative clinical trials focusing on advanced cancer treatments, including studies for leukemia, prostate cancer, and gastric cancer.

Chronic Lymphocytic Leukemia
Metastatic Prostate Cancer
Esophageal Cancer
Advanced Breast Cancer

Studies evaluating novel therapeutic combinations and targeted treatments for various cancer types.

02 Autoimmune Conditions

Research focused on treating inflammatory disorders and autoimmune conditions, with particular emphasis on innovative therapies.

Ulcerative Colitis
Psoriatic Arthritis
Plaque Psoriasis
Multiple Sclerosis

Evaluating new biological treatments and their long-term effectiveness in managing chronic conditions.

03 Respiratory and Cardiovascular

Studies addressing respiratory diseases and heart conditions, focusing on prevention and treatment strategies.

Chronic Obstructive Pulmonary Disease
RSV Prevention
Heart Failure Prevention
Cardiovascular Risk Management

Testing innovative approaches to improve patient outcomes in respiratory and cardiac conditions.

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Clinical trials in Brno – page 5

390 trials in Brno

Chronic lymphocytic leukaemia recurrent+1

A study of acalabrutinib and venetoclax for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma who have relapsed after initial treatment

B-cell small lymphocytic lymphoma

A study comparing BGB-11417 and zanubrutinib with venetoclax and acalabrutinib for patients with previously untreated chronic lymphocytic leukemia

Hereditary haemochromatosis

A study to evaluate the effectiveness and safety of vamifeport in adults with hereditary hemochromatosis

Efficacy and safety of gadopiclenol versus gadoteric acid‑enhanced MRA in adult patients with suspected vascular disease

Efficacy and safety of gadopiclenol versus gadoteric acid‑enhanced MRA in adult patients with suspected vascular disease

Juvenile idiopathic arthritis

A study to evaluate the safety and effectiveness of filgotinib in children and adolescents aged 8 to 17 years with polyarticular juvenile idiopathic arthritis

Acute lymphocytic leukaemia

Study of Blinatumomab and a drug combination for older adults with newly diagnosed Philadelphia-negative B-cell precursor Acute Lymphoblastic Leukemia

Non-small cell lung cancer

Comparing Sotorasib and Pembrolizumab with chemotherapy for patients with advanced non-small cell lung cancer and a KRAS G12C mutation

Squamous cell carcinoma of lung+4

A study of PF-08634404 and a drug combination in adults with advanced or metastatic non-small cell lung cancer

Obstructive sleep apnoea syndrome

Study of Maridebart Cafraglutide for Adults with Obstructive Sleep Apnea and Overweight or Obesity Who Use Positive Airway Pressure Therapy

Acute myeloid leukaemia

Study of Ziftomenib with drug combinations for adults with newly diagnosed acute myeloid leukemia with NPM1 or KMT2A genetic changes

Obstructive sleep apnoea syndrome

A Phase 3 Randomized, Double-blind,Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants with Obstructive Sleep Apnea not on Positive Airway Pressure Therapy and Living with Overweight or Obesity (MARITIME-OSA-2)

Hepatitis D

A study comparing brelovitug to bulevirtide for treating chronic hepatitis delta infection in patients currently receiving bulevirtide

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Clinical research in Brno

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Clinical trials in Brno – page 5

390 trials in Brno

Chronic lymphocytic leukaemia recurrent+1

Squamous cell carcinoma of lung+4

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Clinical research in Brno

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