In short
This article discusses clinical trials investigating the use of Holcus Lanatus Pollen Extract, also known as velvet grass pollen extract, as part of a combination therapy for treating moderate to severe allergic rhinitis or rhinoconjunctivitis caused by house dust mite allergy. The trials aim to assess the efficacy and safety of this treatment approach in adult patients, with a focus on improving symptoms and quality of life.
At a glance
- Study Type
- Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study
- Treatment
- PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy
- Target Condition
- Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite Allergy
- Primary Objective
- Assess clinical efficacy measured by Total Combined Rhinitis Score (TCRS)
- Key Inclusion Criteria
- Adults 18-65 years, history of HDM allergic rhinitis, positive skin prick test, FEV1 > 70%
- Key Exclusion Criteria
- Severe immune disorders, active malignancies, moderate to severe asthma
- Treatment Duration
- Approximately 52 weeks
- Safety Assessments
- Adverse events, local and systemic reactions, impact on asthma parameters
What is Holcus Lanatus Pollen Extract?
Holcus Lanatus Pollen Extract is derived from the pollen of Holcus Lanatus, commonly known as velvet grass. It is one of several grass pollen extracts used in allergy testing and treatment. This extract is part of a broader group of grass pollen allergens that are frequently used in diagnosing and treating grass pollen allergies.
Medical Conditions Treated
Holcus Lanatus Pollen Extract is primarily used in the diagnosis and treatment of allergic conditions related to grass pollen, including:
- Allergic Rhinitis: This is an allergic reaction that causes symptoms in the nose, such as sneezing, itching, and runny or stuffy nose.
- Allergic Rhinoconjunctivitis: This condition affects both the nose and eyes, causing symptoms like those of allergic rhinitis plus eye symptoms such as itchy, watery, or red eyes.
- Allergic Asthma: Some people with grass pollen allergies may also experience asthma symptoms triggered by grass pollen exposure.
How It Works
Holcus Lanatus Pollen Extract works in two main ways:
- Diagnosis: It is used in skin prick tests to diagnose grass pollen allergies. A small amount of the extract is placed on the skin, which is then pricked. If a person is allergic, a small, itchy bump will appear at the site.
- Treatment: As part of allergen immunotherapy, small amounts of the allergen are introduced to the body over time, helping to build tolerance and reduce allergic reactions.
Administration and Dosage
Holcus Lanatus Pollen Extract is typically administered in two ways:
- Skin Prick Test: For diagnostic purposes, a single drop is usually applied to the skin.
- Immunotherapy: For treatment, it may be given as subcutaneous (under the skin) injections. The dosage and frequency are determined by a healthcare provider based on individual patient needs.
Current Clinical Trials
While there are no specific trials mentioned for Holcus Lanatus Pollen Extract alone, it is often included in grass pollen mixture studies. A current clinical trial is investigating the effectiveness of a grass pollen mixture for allergic rhinitis and rhinoconjunctivitis:
- The study is assessing the efficacy of PURETHAL Mites Mixture, a subcutaneous immunotherapy, in adults with moderate to severe allergic rhinitis or rhinoconjunctivitis due to house dust mite allergy.
- This randomized, double-blind, placebo-controlled study aims to evaluate the treatment's effect on symptoms and quality of life over a one-year period.
- The main objective is to assess the difference in Total Combined Rhinitis Score (TCRS) between the treatment and placebo groups.
Potential Side Effects and Precautions
While specific side effects for Holcus Lanatus Pollen Extract are not detailed, allergen immunotherapy can generally cause:
- Local reactions at the injection site (redness, swelling, itching)
- Mild systemic reactions (sneezing, nasal congestion)
- In rare cases, more severe allergic reactions
Precautions:
- Always use under medical supervision
- Inform your doctor of any other allergies or medical conditions
- Follow-up appointments are crucial to monitor progress and adjust treatment as needed
It's important to discuss potential risks and benefits with a healthcare provider before starting any new treatment.