In short
Perampanel, also known by its brand name Fycompa, is a medication being studied in clinical trials for the treatment of epilepsy and seizures. These trials aim to evaluate its effectiveness, safety, and optimal dosing when used alone or in combination with other anti-epileptic drugs. Researchers are investigating perampanel in various forms, including oral tablets, oral suspension, and intravenous infusions, to understand its potential benefits for patients with different types of seizures.
At a glance
- Drug Name
- Perampanel (Brand name: Fycompa)
- Indications Studied
- Partial-onset seizures, Generalized tonic-clonic seizures, Idiopathic generalized epilepsy
- Administration Forms
- Oral tablets, Oral suspension, Intravenous infusion
- Dosage Range
- 2 mg to 12 mg daily
- Primary Outcomes
- Retention rate, Seizure frequency reduction, Safety profile
- Secondary Outcomes
- Seizure freedom rates, Quality of life measures, Pharmacokinetic parameters
- Patient Populations
- Adults and adolescents (12 years and older) with epilepsy, Healthy volunteers for pharmacokinetic studies
- Study Designs
- Randomized controlled trials, Open-label studies, Observational studies, Bioequivalence studies
- Key Safety Assessments
- Adverse events monitoring, Laboratory tests, Vital signs, ECG
What is Perampanel?
Perampanel is a medication used to treat certain types of seizures in people with epilepsy. It is also known by its brand name Fycompa or by its research code E2007. Perampanel is classified as an anti-epileptic drug (AED) and is typically used as an add-on treatment, which means it is given in addition to other seizure medications.
Medical Conditions Treated
Perampanel is used to treat the following types of seizures:
- Partial-onset seizures (also called focal seizures): These are seizures that start in one part of the brain.
- Secondarily generalized seizures: These are partial-onset seizures that spread to involve both sides of the brain.
- Primary generalized tonic-clonic seizures (PGTC): These are seizures that involve the entire brain from the start.
Perampanel is approved for use in patients aged 12 years and older with these types of seizures.
How Perampanel Works
Perampanel works by targeting specific receptors in the brain called AMPA receptors. These receptors are involved in the transmission of electrical signals between brain cells. By blocking these receptors, Perampanel helps to reduce excessive electrical activity in the brain that can lead to seizures.
Forms and Administration
Perampanel comes in several forms:
- Oral tablets
- Oral suspension (a liquid form)
- Intravenous (IV) infusion (in some clinical trials)
The most common form is the oral tablet, which is typically taken once daily before bedtime. The dose is usually started low and gradually increased based on the patient's response and tolerance to the medication.
Effectiveness
Several studies have shown that Perampanel can be effective in reducing seizure frequency in patients with epilepsy. Some key findings include:
- Reduction in seizure frequency: Many patients experience a significant decrease in the number of seizures they have.
- Seizure freedom: Some patients may become completely seizure-free while taking Perampanel.
- Long-term effectiveness: Studies have shown that Perampanel can remain effective for extended periods, with some patients continuing to benefit from the medication for 12 months or longer.
Side Effects and Safety
Like all medications, Perampanel can cause side effects. Common side effects may include:
- Dizziness
- Sleepiness
- Irritability
- Falls
- Problems with coordination
More serious side effects, though less common, can include changes in mood or behavior, such as aggression or suicidal thoughts. It's important to report any side effects to your healthcare provider.
Special Considerations
There are some special considerations to keep in mind when taking Perampanel:
- Driving and operating machinery: Perampanel can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery safely.
- Alcohol: Drinking alcohol while taking Perampanel may increase side effects like dizziness and sleepiness.
- Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Perampanel with your doctor.
- Other medications: Perampanel can interact with other medications, including some birth control pills. Always inform your doctor about all medications you are taking.
Remember, Perampanel is a prescription medication that should only be taken under the guidance of a healthcare professional. Never adjust your dose or stop taking the medication without consulting your doctor first.