In short
This article discusses the use of Suxamethonium Chloride Dihydrate in clinical trials, particularly focusing on its application in pediatric anesthesia for orthopedic trauma surgery. The drug, also known as Succinylcholine, is being studied as part of a broader investigation into preventing persistent postoperative pain in children through the use of locoregional analgesia techniques.
At a glance
- Study Drug
- Suxamethonium Chloride Dihydrate (SUXAMETHONIUM AGUETTANT 10 mg/mL)
- Study Population
- Children aged 5 to under 15 years and 3 months
- Medical Condition
- Post-operative pain after orthopedic trauma surgery
- Main Objective
- Evaluate locoregional analgesia for preventing persistent postoperative pain
- Study Design
- Randomized trial with two arms: Locoregional Analgesia + general anesthesia vs. General anesthesia alone
- Primary Endpoint
- Pain measurement using Numerical Rating Scale at 3 months post-surgery
- Key Secondary Endpoints
- Neuropathic pain, immediate post-operative pain, opioid consumption
- Drug Administration
- Intravenous bolus injection/IV infusion
- Maximum Daily Dose
- 1 mg/kg
What is Suxamethonium Chloride Dihydrate?
Suxamethonium Chloride Dihydrate is a medication used in medical procedures, particularly during surgeries. It belongs to a class of drugs known as neuromuscular blocking agents. This medication is also referred to as Suxamethonium or Succinylcholine.
Medical Uses
Suxamethonium is primarily used in anesthesia. Its main purpose is to cause short-term paralysis of the muscles, which is particularly useful during certain medical procedures. Some common scenarios where Suxamethonium might be used include:
- To facilitate endotracheal intubation (inserting a breathing tube)
- During short surgical procedures that require muscle relaxation
- In emergency situations where rapid muscle paralysis is needed
How is it Administered?
Suxamethonium Chloride Dihydrate is administered via intravenous injection or infusion. This means it's given directly into a vein. The specific product mentioned in the clinical trial data is "SUXAMETHONIUM AGUETTANT 10 mg/mL, solution injectable en seringue préremplie," which translates to "Suxamethonium Aguettant 10 mg/mL, solution for injection in a pre-filled syringe."
Dosage Information
The dosage of Suxamethonium is carefully calculated by healthcare professionals based on various factors including the patient's weight, age, and the specific medical procedure. According to the clinical trial information, the maximum daily dose is 1 mg/kg (milligram per kilogram of body weight). It's important to note that this medication should only be administered by trained medical personnel in a controlled setting.
Other Names for Suxamethonium
Suxamethonium Chloride Dihydrate is known by several other names, which include:
- Succinylcholine chloride dihydrate
- Succinylcholine dichloride dihydrate
- Suxamethonium dichloride dihydrate
Precautions and Considerations
While Suxamethonium is an effective and widely used medication in anesthesia, there are several important considerations:
- It should only be used under the supervision of trained anesthesiologists or other qualified healthcare professionals.
- The medication causes temporary muscle paralysis, including the muscles used for breathing. Therefore, patients receiving this medication will need assistance with breathing during its effects.
- It's classified as an auxiliary medication in the clinical trial context, meaning it's used to support the main treatment or procedure rather than being the primary focus of the study.
- As with any medication, there can be potential side effects or contraindications. These should be discussed with your healthcare provider if you're scheduled for a procedure where Suxamethonium might be used.
Remember, Suxamethonium Chloride Dihydrate is a specialized medication used in specific medical contexts. If you have any questions or concerns about its use in your medical care, always consult with your healthcare provider for personalized information and advice.