Rare diseases
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Clinical trials in Croatia276 clinical trials in Croatia across 8 research sites in 26 cities. Every trial is listed in the EU Clinical Trials Register and updated daily.
Our site in CroatiaKlinicka-Ispitivanja.hr(opens in a new tab)CroatiaCroatiaCroatiaCroatiaCroatiaCroatiaCroatiaCroatiaCroatiaCroatiaCroatiaCroatiaWhere most of the country's trials are run
Shares are of these cities' trials together.
26 cities, A–Z – pick yours to filter the trials
What the registry says about research in the country
Clinical research in Croatia encompasses extensive studies on inflammatory bowel diseases, particularly ulcerative colitis and Crohn's disease. These trials focus on evaluating novel therapeutic agents designed to induce and maintain clinical remission in patients with moderately to severely active disease. The research aims to improve treatment outcomes for individuals who have not responded adequately to conventional therapies.
These studies contribute to advancing therapeutic options for patients suffering from chronic intestinal inflammation, with the goal of achieving sustained disease control and improving quality of life.
Research facilities across Croatia are actively investigating treatments for multiple sclerosis and related neurological conditions. Studies encompass various forms of MS, including relapsing-remitting, primary progressive, and secondary progressive multiple sclerosis. The trials evaluate both new therapeutic agents and long-term extension studies to assess sustained efficacy and safety profiles.
This research addresses the need for improved disease-modifying therapies that can reduce relapse rates, slow disease progression, and enhance neurological outcomes for patients living with these chronic conditions.
Croatian research sites participate in comprehensive oncology trials covering a broad spectrum of malignancies. Studies focus on non-small cell lung cancer, melanoma, breast cancer, renal cell carcinoma, and various hematologic malignancies including chronic lymphocytic leukemia, multiple myeloma, and diffuse large B-cell lymphoma. These investigations evaluate novel immunotherapies, targeted agents, and combination treatment regimens.
The research aims to improve survival outcomes, delay disease progression, and enhance the quality of life for cancer patients through innovative treatment approaches and precision medicine strategies.
Clinical trials in Croatia address various autoimmune conditions including rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and Sjögren's syndrome. Research efforts concentrate on evaluating advanced immunomodulatory therapies, including JAK inhibitors and biologic agents, for patients who have inadequate responses to conventional disease-modifying treatments.
These studies seek to provide more effective options for controlling disease activity, preventing structural joint damage, and reducing the systemic manifestations of autoimmune disorders.
Dermatological research in Croatian clinical centers encompasses studies on atopic dermatitis, psoriatic conditions, hidradenitis suppurativa, and rare skin disorders such as bullous pemphigoid and epidermolysis bullosa. Trials evaluate both pediatric and adult populations, focusing on moderate to severe disease presentations that require systemic intervention.
The research addresses unmet needs in dermatology by investigating treatments that can achieve significant disease control and improve the quality of life for patients with debilitating skin conditions.
Croatian institutions conduct trials on various cardiovascular conditions, including atrial fibrillation, heart failure, acute coronary syndrome, and atherosclerotic cardiovascular disease. Research focuses on anticoagulation strategies, heart failure management in patients with preserved or mildly reduced ejection fraction, and prevention of recurrent cardiovascular events.
These studies aim to reduce cardiovascular morbidity and mortality through improved therapeutic strategies and better management of complex cardiac conditions.
Research on kidney diseases in Croatia includes studies on IgA nephropathy, focal segmental glomerulosclerosis, and chronic kidney disease-related complications. Trials evaluate novel agents targeting proteinuria reduction, preservation of renal function, and management of anemia in patients with kidney disease.
The research seeks to slow disease progression, reduce the burden of kidney disease complications, and improve outcomes for patients at risk of renal failure.
Clinical trials address respiratory conditions including chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, and pulmonary arterial hypertension. Studies evaluate treatments for severe eosinophilic asthma, progressive fibrosing interstitial lung diseases, and bronchiectasis, focusing on improving lung function and reducing disease progression.
These investigations aim to provide better symptom control, slow disease progression, and improve exercise capacity and quality of life for patients with chronic respiratory conditions.
Croatian research sites participate in studies on hematologic conditions including hemophilia A and B, immune thrombocytopenia, myelofibrosis, and polycythemia vera. Research evaluates novel factor replacement therapies, gene therapies, and treatments for patients with and without inhibitors, as well as management strategies for myeloproliferative neoplasms.
The research focuses on improving bleeding control, reducing treatment burden, and enhancing quality of life for patients with hereditary and acquired blood disorders.
Studies on neurological disorders include investigations of focal onset seizures, primary generalized tonic-clonic seizures, and refractory status epilepticus. Croatian centers also participate in research on Alzheimer's disease-related conditions, including agitation and psychosis, as well as studies on spinal muscular atrophy.
These trials seek to improve seizure control, address behavioral symptoms in dementia, and provide new therapeutic options for patients with difficult-to-treat neurological conditions.
Research in ophthalmology focuses on neovascular age-related macular degeneration, diabetic macular edema, and geographic atrophy. Studies evaluate novel anti-VEGF agents and other therapeutic approaches aimed at preserving or improving visual acuity in patients with retinal diseases.
The research aims to prevent vision loss, improve visual outcomes, and reduce treatment burden for patients with sight-threatening retinal conditions.
Clinical trials address metabolic conditions including type 2 diabetes, obesity, non-alcoholic steatohepatitis, and lipid disorders such as familial chylomicronemia syndrome and severe hypertriglyceridemia. Research evaluates novel therapeutic agents for glycemic control, weight management, and cardiovascular risk reduction.
These studies focus on improving metabolic control, reducing cardiovascular complications, and addressing the growing burden of metabolic diseases.
Research on infectious diseases includes studies on complicated urinary tract infections, acute pyelonephritis, diabetic foot infections, and hospital-acquired pneumonia. Trials evaluate novel antimicrobial agents with activity against resistant pathogens and assess their safety and efficacy compared to standard treatments.
The research addresses the critical need for effective treatments against multidrug-resistant bacteria and aims to improve outcomes in serious bacterial infections.
Croatian clinical centers participate in studies on mental health conditions including schizophrenia, treatment-resistant schizophrenia, bipolar I disorder, major depressive disorder, and tardive dyskinesia. Research evaluates novel antipsychotics, mood stabilizers, and treatments for movement disorders associated with psychiatric medications.
These trials aim to provide more effective and better-tolerated treatments for patients with severe mental illness and to address medication-related complications.
Research includes studies on rare conditions such as hereditary angioedema, transthyretin amyloidosis with cardiomyopathy, chronic inflammatory demyelinating polyneuropathy, antiphospholipid syndrome, and Behçet's syndrome. Trials evaluate specialized therapies designed to address the unique pathophysiology of these uncommon disorders.
This research provides hope for patients with rare diseases by investigating treatments specifically designed for their conditions, potentially improving outcomes where few therapeutic options previously existed.
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