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Clinical trials in Slovenia – page 7103 clinical trials in Slovenia across 3 research sites in 17 cities. Every trial is listed in the EU Clinical Trials Register and updated daily.
Our site in SloveniaKlinicnaPreskusanja.si(opens in a new tab)SloveniaSloveniaSloveniaSloveniaSloveniaSloveniaSloveniaSloveniaSloveniaSloveniaSloveniaSloveniaWhere most of the country's trials are run
Shares are of these cities' trials together.
17 cities, A–Z – pick yours to filter the trials
What the registry says about research in the country
Slovenia is actively engaged in clinical trials focused on various forms of cancer, including both solid tumors and hematological malignancies. Research efforts concentrate on non-small cell lung cancer with specific genetic mutations such as KRAS G12C, as well as melanoma, particularly in completely resected stages. Studies investigate breast cancer subtypes, including ER-positive HER2-negative and triple-negative breast cancer, alongside ovarian cancer with BRCA mutations. Additional focus areas include endometrial cancer, head and neck squamous cell carcinoma, colon cancer, and pancreatic cancer. Pediatric oncology trials address conditions such as acute lymphoblastic leukemia, neuroblastoma, rhabdomyosarcoma, and low-grade glioma with specific genetic alterations.
These trials evaluate novel immunotherapies, targeted molecular therapies, and combination treatment regimens aimed at improving progression-free survival, overall survival, and disease-free survival outcomes across diverse cancer populations.
Clinical research in Slovenia addresses multiple aspects of cardiovascular disease, with particular emphasis on acute myocardial infarction complicated by cardiogenic shock and heart failure with varying ejection fractions. Studies investigate atherosclerotic cardiovascular disease prevention and management, focusing on LDL-cholesterol reduction strategies. Research also examines arterial hypertension control through various pharmacological combinations and acute pulmonary embolism management with intermediate-high risk. Additional areas include acute myocarditis with severe cardiac inflammation, exploring both standard and intensified treatment approaches.
These investigations aim to establish optimal treatment protocols for cardiovascular emergencies and chronic conditions, evaluating both efficacy and safety of therapeutic interventions in real-world clinical settings.
Slovenian research sites participate in trials examining various neurological conditions, with substantial focus on multiple sclerosis subtypes including relapsing-remitting, secondary progressive, and relapsing forms. Studies evaluate disease-modifying therapies aimed at reducing relapse frequency and slowing disease progression. Research also addresses amyotrophic lateral sclerosis, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. Pediatric neurological research includes GRIN-related disorders and refractory focal onset epilepsy, examining both seizure control and behavioral symptom management.
The trials investigate mechanisms to preserve neurological function, reduce disability progression, and improve quality of life for patients with chronic and progressive neurological diseases.
Clinical trials in Slovenia extensively investigate treatments for inflammatory bowel diseases, specifically Crohn's disease and ulcerative colitis ranging from moderate to severe activity. Research evaluates various biologic therapies and targeted small molecules, including maintenance strategies following successful induction treatment. Studies compare different dosing regimens and assess long-term safety profiles of novel therapeutic agents. Some trials employ therapeutic drug monitoring approaches versus clinical assessment for dose optimization, aiming to achieve and maintain disease remission while minimizing treatment-related adverse effects.
These investigations seek to establish effective treatment algorithms for inflammatory bowel disease management, with emphasis on achieving sustained clinical and endoscopic remission.
Slovenia participates in research addressing rare conditions including phenylketonuria, Pompe disease, and Duchenne muscular dystrophy. Studies evaluate enzyme replacement therapies, substrate reduction approaches, and novel pharmacological chaperones. Research also encompasses familial hypercholesterolemia in both heterozygous and homozygous forms, investigating long-term lipid management strategies. Pediatric growth disorders receive attention, including conditions such as Turner syndrome, Noonan syndrome, and idiopathic short stature, along with children born small for gestational age. Additional focus includes CTNNB1 syndrome and other congenital abnormalities.
These trials aim to improve metabolic control, enhance growth outcomes, and address the underlying pathophysiology of rare genetic disorders through innovative therapeutic approaches.
Clinical research addresses various hematological conditions, with particular emphasis on hemophilia A and B management through extended half-life factor replacement therapies. Studies evaluate prophylactic treatment regimens, assessing joint health outcomes, bleeding episode management, and physical activity levels in patients receiving once-weekly dosing. Research also investigates atypical hemolytic uremic syndrome, examining complement inhibition strategies in treatment-naive patients. Additional areas include fetal and neonatal alloimmune thrombocytopenia prevention and management of acquired antithrombin deficiency in patients requiring anticoagulation reversal for urgent surgical procedures.
These investigations focus on improving bleeding disorder management, preventing complications, and enhancing patient quality of life through optimized treatment strategies.
Slovenia conducts trials examining various respiratory tract diseases, including severe asthma with eosinophilic phenotype and moderate-to-severe uncontrolled asthma requiring advanced therapeutic interventions. Research investigates idiopathic pulmonary fibrosis and progressive pulmonary fibrosis, evaluating treatments aimed at slowing disease progression and preserving lung function. Studies also address progressive fibrosing interstitial lung diseases, examining both short-term efficacy and long-term safety of novel anti-fibrotic agents. The research includes evaluation of biologic therapies targeting specific inflammatory pathways in asthma management.
These trials aim to establish effective treatment options for patients with difficult-to-treat respiratory diseases, focusing on symptom control, exacerbation prevention, and disease modification.
Clinical research addresses multiple autoimmune diseases, with studies investigating psoriatic arthritis and Sjögren's syndrome with varying degrees of systemic involvement. Research evaluates combination therapies and novel biologic agents targeting specific immune pathways. Studies also examine IgA nephropathy, also known as Berger's disease, investigating treatments aimed at reducing proteinuria and preserving renal function. Additional focus includes immune system diseases affecting multiple organ systems, evaluating both efficacy and safety of immunomodulatory interventions. The trials assess disease activity measures, symptom burden, and quality of life outcomes.
These investigations seek to optimize management of autoimmune conditions, balancing therapeutic efficacy with safety considerations in long-term treatment.
Slovenian research sites participate in trials examining type 1 diabetes and type 2 diabetes, investigating novel therapeutic approaches for glycemic control and disease modification. Studies in type 1 diabetes mellitus evaluate interventions aimed at preserving endogenous insulin secretion in newly diagnosed patients, particularly in adolescent and young adult populations. Research also addresses hormonal diseases and metabolic disorders, examining treatments for various endocrine dysfunctions. Additional focus includes thyroid eye disease, investigating therapies to reduce disease activity and improve orbital manifestations.
These trials aim to improve diabetes management, prevent complications, and explore disease-modifying interventions that may alter the natural history of endocrine disorders.
Clinical trials investigate various skin and connective tissue diseases, with particular focus on atopic dermatitis and hidradenitis suppurativa. Research evaluates novel biologic therapies and targeted treatments aimed at reducing disease severity, controlling inflammation, and improving skin-related quality of life. Studies assess both short-term efficacy and long-term safety profiles of therapeutic interventions in patients with moderate to severe disease who have inadequate response to conventional treatments. The trials examine various outcome measures including disease activity scores, symptom burden, and patient-reported outcomes.
These investigations aim to establish effective treatment options for patients with chronic inflammatory skin diseases, focusing on sustained disease control and improved patient outcomes.
Research in Slovenia includes studies addressing end-stage chronic kidney disease in highly sensitized patients awaiting kidney transplantation, investigating strategies to improve transplant access and outcomes. Additional focus includes CMV infection prevention and management in heart transplant recipients, evaluating antiviral prophylaxis strategies. Studies also examine conditions affecting specific organ systems, including eye diseases and otorhinolaryngologic diseases, investigating both medical and surgical interventions. Research addresses fecal incontinence in both male and female patients, exploring therapeutic options to improve continence and quality of life.
These trials investigate interventions to optimize transplant outcomes, prevent complications, and address functional impairments across various organ systems.
Clinical research addresses virus diseases and respiratory tract infections, with studies participating in adaptive platform trials for community-acquired pneumonia. Research evaluates various interventions for hospitalized patients with acute respiratory tract infection, assessing effects on mortality and illness trajectory. Studies also investigate the impact of probiotics and antibiotics on gut microbiota in patients receiving antibiotic therapy for conditions such as erythema migrans, the early skin manifestation of Lyme borreliosis. The research examines both treatment efficacy and microbiome preservation strategies during antimicrobial therapy.
These investigations aim to optimize infectious disease management while minimizing treatment-related complications and preserving beneficial microbial populations.
Slovenia participates in research examining dementia of the Alzheimer's type, investigating treatments for both cognitive symptoms and behavioral manifestations such as agitation. Studies evaluate novel therapeutic approaches in patients with mild cognitive impairment or mild dementia, assessing effects on cognition and functional abilities through standardized rating scales. Research focuses on disease-modifying interventions that may slow cognitive decline and improve quality of life for patients and caregivers. The trials employ comprehensive outcome measures including the Clinical Dementia Rating – Sum of Boxes to assess treatment effects on cognition and function.
These trials aim to establish interventions that may alter the course of neurodegenerative diseases and improve management of associated behavioral symptoms.
Clinical research addresses various musculoskeletal diseases, with particular emphasis on joint health assessment in patients with hemophilia receiving prophylactic factor replacement therapy. Studies employ ultrasound imaging to monitor joint status and evaluate the impact of treatment on preventing arthropathy. Research also examines physical activity levels and their correlation with joint outcomes in adolescent and adult patients with severe hemophilia. Additional focus includes musculoskeletal and neural physiological phenomena, investigating the interplay between treatment regimens and functional outcomes. The trials assess both objective joint health measures and patient-reported physical activity data.
These investigations aim to optimize musculoskeletal health in patients with chronic conditions, focusing on prevention of joint damage and maintenance of physical function.
Slovenia contributes to critical care research addressing traumatic injury management in severely ill patients. Studies evaluate interventions aimed at reducing mortality and preventing severe disability in critically ill trauma populations, examining both short-term and long-term outcomes. Research also investigates hemodynamic management strategies in patients with cardiogenic shock, comparing different blood pressure targets and vasoactive medication approaches. The trials assess composite endpoints including survival, organ function preservation, and neurological outcomes at extended follow-up periods. Additional focus includes optimal supportive care strategies and timing of interventions in critically ill populations.
These investigations seek to establish evidence-based approaches for managing critical illness, balancing aggressive intervention with potential treatment-related complications in vulnerable patient populations.
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