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Coronary artery occlusion Trials in Disease

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Clinical trials for Coronary artery occlusion

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1 clinical trial in this condition

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Study on Theophylline, Gadoteric Acid, and Regadenoson for Patients with Chronic Total Coronary Artery Blockage

Registered drugNo placebo
Countries:SpainSpain
  • Participants:18–64 years · 65+ years
  • Substances:Gadoteric Acid
  • Sponsor:Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer
See all 1 trials →filters applied: condition = Coronary artery occlusion

In short

Currently, there are 2 ongoing clinical trials investigating treatments and diagnostic approaches for coronary artery occlusion. These trials are taking place in France and Spain, focusing on optimizing medication duration after stent placement and improving imaging techniques to assess heart health in patients with chronic blockages.

Clinical trial locations

Study on Dual Antiplatelet Therapy Duration for Patients with Chronic Coronary Artery Blockage Using Clopidogrel and D,L-Lysine Acetylsalicylate

This trial is being conducted in France and focuses on patients who have undergone a successful procedure to open a chronically blocked coronary artery using a stent. The study compares two different durations of dual antiplatelet therapy, which involves taking two medications to prevent blood clots.

Main inclusion criteria: Participants must be over 18 years old and have had a successful stent placement in a blocked heart artery. They must be able to take aspirin for a long period and require dual antiplatelet therapy. All participants need to be part of the Social Security system and provide informed consent.

Main exclusion criteria: Patients with a chronically occluded coronary artery that has not been treated, those outside the specified age range, and individuals from vulnerable populations cannot participate.

Focus and goal: The study aims to determine whether a shorter duration of dual antiplatelet therapy lasting 1 month is as safe and effective as the standard 6 to 12 months. Researchers will monitor participants for 12 months to track adverse events such as bleeding or heart-related problems, assess quality of life, and evaluate treatment costs.

Investigational drugs: The trial uses clopidogrel, a medication that makes blood less sticky to prevent clots, and aspirin in the form of D,L-Lysine Acetylsalicylate, which also helps prevent blood clots. Both medications are taken orally.

Study on Theophylline, Gadoteric Acid, and Regadenoson for Patients with Chronic Total Coronary Artery Blockage

This trial is taking place in Spain and involves patients with a complete blockage in a coronary artery that has been present for an extended period. The study aims to improve understanding of how different imaging techniques can assess heart muscle health and blood flow.

Main inclusion criteria: Participants must be 18 years or older and have a chronic total occlusion in a native coronary artery. The blood vessel beyond the blockage should have a diameter of at least 2.5 mm. Patients must be able to provide informed consent and willing to attend scheduled follow-up appointments and tests.

Main exclusion criteria: Patients with a different heart condition than chronic total occlusion, those outside the specified age range, and individuals from vulnerable populations not included in the study cannot participate.

Focus and goal: The study evaluates the effectiveness of several imaging techniques, including coronary CT angiography, myocardial perfusion imaging, and stress cardiac MRI. These tests help doctors visualize blood flow to the heart and identify areas not receiving enough blood. Participants will undergo imaging tests at the beginning of the study and again after six months to assess any changes in heart structure and function.

Investigational drugs and techniques: The trial uses several substances to enhance imaging: theophylline anhydrous, which helps open airways in the lungs; gadoteric acid, a contrast agent that makes blood vessels more visible on MRI scans; and regadenoson, a medication that widens the blood vessels of the heart. These are administered intravenously during imaging procedures.

Summary

The two ongoing clinical trials for coronary artery occlusion reflect different approaches to managing this condition. The French trial focuses on optimizing medication duration after stent placement, specifically comparing shorter versus longer dual antiplatelet therapy to balance effectiveness with potential bleeding risks. The Spanish trial takes a diagnostic approach, using advanced imaging techniques to better evaluate heart muscle health and blood flow in patients with chronic blockages.

These trials are geographically distinct, with one in France and one in Spain, each addressing important clinical questions that could improve treatment strategies and diagnostic capabilities for patients with blocked coronary arteries. Both studies emphasize patient safety through careful monitoring of adverse events and follow-up assessments.

This guide is here to help you understand the condition. It does not replace a conversation with your doctor, who knows your situation best.

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