Gastrectomy Trials in Disease

Study on the Effects of Amylase, Protease, and Rizolipase for Patients After Gastrectomy

This clinical trial is designed for patients who have undergone gastrectomy and are experiencing challenges with digestion and quality of life afterward. The study aims to evaluate whether taking a digestive enzyme supplement called Nortase® with every meal can improve daily well-being six months after surgery.

Who can participate:

• Adults aged 18 years or older
• Patients who have had gastrectomy (removal of part or all of the stomach)
• Both men and women are eligible

Who cannot participate:

The exclusion criteria indicate that patients who have had gastrectomy are the focus of this study, so specific exclusions beyond this primary condition are not detailed in the available information.

What the trial focuses on:

The main goal of this research is to determine if enzyme supplementation can lead to better disease-specific quality of life for patients recovering from gastrectomy. After stomach removal, the body may struggle to produce enough digestive enzymes, leading to symptoms such as bloating, gas, diarrhea, and difficulty absorbing nutrients. This trial investigates whether Nortase® can help alleviate these symptoms and improve physical well-being.

How the trial works:

Participants will be randomly assigned to receive either Nortase® or a placebo (an inactive substance). The study will last for six months, during which participants will take capsules with their meals. Throughout the trial, regular follow-up appointments will monitor health status and quality of life using questionnaires and physical assessments. At the end of the six-month period, a comprehensive evaluation will compare outcomes between those taking the enzyme supplement and those taking the placebo.

Investigational medication:

Nortase® contains pancreatic enzymes including amylase, protease, and rizolipase. These enzymes help break down carbohydrates, proteins, and fats in food, making it easier for the body to absorb nutrients. This type of supplementation is particularly important after gastrectomy, as the altered digestive system may not produce sufficient enzymes naturally. By supporting digestion, these enzymes may reduce common post-surgical symptoms and improve nutritional status.