Post procedural oedema Trials in Disease

Study on the Effects of Horse Chestnut Seed Extract on Swelling and Pain in Patients After Meniscus Surgery

This clinical trial is investigating whether a natural medication called Aescuven, made from horse chestnut seed extract, can help reduce swelling, pain, and fluid buildup after meniscus surgery. The study compares the effects of Aescuven to a placebo, which looks identical but contains no active ingredients, ensuring that neither participants nor researchers know who receives which treatment during the study.

Main inclusion criteria:

• You must be between 18 and 75 years old
• You must have a diagnosis requiring meniscus arthroscopy on one knee
• Your surgery must be scheduled within 5 months of the initial screening visit
• You must be able to understand the trial, sign a consent form, and attend all required visits

Main exclusion criteria:

• You cannot participate if you do not experience post-operative swelling, pain, and fluid buildup after meniscus surgery
• You cannot be outside the specified age range
• You cannot be part of a vulnerable population, such as children, pregnant women, or those unable to give consent

What the trial involves:

The trial follows a structured timeline with several steps. At the initial visit, the study will be explained in detail, and you will sign a consent form. Before surgery, your knee will be carefully measured to record its volume, circumference, range of motion, and skin temperature. After your meniscus surgery, you will begin taking the study medication: four tablets of Aescuven daily, divided into two doses taken twice per day.

Throughout the study, you will attend several follow-up visits where your knee will be measured again to track any changes in swelling. The amount of pain medication you use will also be recorded. At the final visit, you will complete a questionnaire about your quality of life, and the researchers will evaluate how well the medication worked.

Investigational drug:

The medication being tested is Aescuven, which contains a standardized dry extract from horse chestnut seeds rich in compounds called triterpene glycosides. This herbal extract is thought to work by improving blood circulation and reducing fluid retention in tissues, which may help decrease swelling and pain after surgery. Researchers want to find out if this natural treatment can effectively manage post-surgical symptoms and support a more comfortable recovery.