Azienda Ospedaliera Santobono Pausilipon

At Azienda Ospedaliera Santobono Pausilipon in Naples, a major focus is hemic and lymphatic diseases, especially pediatric acute lymphoblastic leukemia, acute myeloid leukemia, and relapsed or high-risk blood cancers. The trials are designed to improve survival, refine treatment strategies, and test newer immunotherapy and targeted approaches for children and adolescents.

• Studies in acute lymphoblastic leukemia, including relapsed, refractory, and Philadelphia chromosome-positive disease
• Research in acute myeloid leukemia, including genetic subtypes and treatment-resistant cases
• Evaluation of immunotherapy, targeted therapy, and treatment intensification to improve outcomes
• Work on hematopoietic stem cell transplantation and post-transplant relapse prevention

This program reflects a strong commitment to better disease control, safer treatment, and more personalized care for young patients with complex blood cancers.

Clinical research here also covers neoplasms of the brain and soft tissues, with studies in neuroblastoma, glioma, medulloblastoma, ependymoma, diffuse intrinsic pontine glioma, osteosarcoma, and Ewing sarcoma. These trials aim to improve tumor control, survival, and quality of life through better systemic therapy and radiation-based strategies.

• Trials in high-risk neuroblastoma to strengthen treatment response and reduce relapse
• Studies in brain tumors such as glioma, medulloblastoma, ependymoma, and DIPG
• Research in Ewing sarcoma and osteosarcoma to compare treatment approaches and improve outcomes
• Testing of targeted and immunotherapy options for difficult-to-treat pediatric tumors

The site’s oncology team is involved in studies that seek more effective treatment combinations while limiting long-term toxicity in children and young adults.

A notable area of research at Azienda Ospedaliera Santobono Pausilipon involves skin and connective tissue diseases, especially severe burns and large skin defects in children and adults. These trials focus on improving wound closure, scar quality, and recovery after major skin injury.

• Studies in deep partial and full-thickness burns
• Research for large full-thickness skin defects in children and adults
• Evaluation of new skin graft and wound repair approaches
• Assessment of healing outcomes and reduction of scarring

This work aims to support better reconstructive care and faster recovery after severe tissue damage.

The site also conducts trials in hemophilia and inherited bleeding disorders, within the broader field of hemic diseases. These studies are intended to improve bleeding control, safety, and day-to-day management for children with rare coagulation disorders.

• Research in hemophilia A and severe inherited von Willebrand disease
• Evaluation of treatments for non-surgical bleeding episodes
• Studies of hemostatic efficacy and treatment tolerability in pediatric patients
• Support for safer care in children with chronic bleeding risk

These trials contribute to more reliable bleeding prevention and improved quality of life for affected families.

Additional studies at the site address nervous system diseases and digestive system diseases, including generalized myasthenia gravis, gastrointestinal graft-versus-host disease, and bowel preparation in children. The purpose is to improve symptom control, treatment safety, and supportive care in complex pediatric conditions.

• Trials in generalized myasthenia gravis to assess safety and long-term tolerability of newer treatments
• Research in gastrointestinal aGvHD to help children after prior treatment failure
• Studies on bowel cleansing for pediatric colonoscopy preparation
• Supportive-care research aimed at improving comfort and treatment success

Together, these studies show a broad clinical research portfolio that extends beyond oncology into rare neurological and gastrointestinal care.