A Phase 3 Study of Orelabrutinib to Delay Disability Progression in Patients with Non‑Active Secondary Progressive Multiple Sclerosis
- Substances:–
France- Participants:18–64 years
- Sponsor:Zenas Biopharma (USA) LLC
Rare diseases
Investigational molecules
Locations
30 Voie Romaine, 06000 Nice, France
Centre Hospitalier Universitaire De Nice in Nice, France specialises in clinical trials of conditions such as Acute myeloid leukaemia, Idiopathic pulmonary fibrosis, Amyotrophic lateral sclerosis, Arteriosclerosis, and other specialisations. This site conducts important research.
At Centre Hospitalier Universitaire De Nice, the Neurology department is involved in research on Nervous System Diseases, with a strong focus on conditions such as multiple sclerosis, Parkinson’s disease, generalized myasthenia gravis, and facioscapulohumeral muscular dystrophy. These studies are designed to assess new treatment options, compare established therapies, and better understand how to slow disease progression and improve daily function.
This area reflects a broad effort to improve both symptom management and long-term outcomes for people living with complex neurological conditions.
The site is also active in Cardiovascular Diseases, including studies in acute coronary syndrome, atherosclerotic cardiovascular disease, atrial fibrillation, and stroke prevention. Research here aims to test whether new treatments can lower the risk of heart attack, stroke, and other major cardiovascular events while balancing safety concerns such as bleeding risk.
These studies support better prevention and long-term management of serious vascular disease in patients at elevated risk.
Clinical trials at this hospital in Nice include important work in Respiratory Tract Diseases, especially idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, interstitial lung disease, bronchiectasis, and asthma. The main goal is to evaluate therapies that may improve lung function, reduce flare-ups, and slow worsening of chronic lung disorders.
This research area is centered on finding better ways to preserve breathing capacity and quality of life in patients with chronic respiratory disease.
The research portfolio also covers Immune System Diseases and Musculoskeletal Diseases, with studies in rheumatoid arthritis, dermatomyositis, and systemic sclerosis-associated interstitial lung disease. These trials are focused on comparing treatment strategies, reducing inflammation, and improving symptoms and physical function in autoimmune conditions.
This work highlights the site’s role in advancing care for chronic inflammatory diseases that can affect both joints and internal organs.
Beyond the major disease groups, Centre Hospitalier Universitaire De Nice contributes to studies in Analytical, Diagnostic and Therapeutic Techniques and Equipment, including research aimed at improving procedures and treatment support. One example is work on kidney stone management, where trials assess whether new supportive strategies can improve stone clearance and recovery after treatment.
This mixed research activity shows a broad commitment to refining patient care across several clinical fields, not only disease treatment but also the tools and approaches used to deliver it.
Clinical trials currently enrolling participants at this site.
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