University Hospital Jena KöR

At University Hospital Jena KöR, a major share of research focuses on oncology and hematology, with studies spanning blood cancers, solid tumors, and transplant-related care. The trials aim to improve treatment effectiveness, refine risk-adapted care, and test new therapeutic combinations for difficult-to-treat diseases.

• Acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndromes
• Diffuse large B-cell lymphoma, Hodgkin lymphoma, and other lymphomas
• Breast cancer, lung cancer, urothelial cancer, and renal cell carcinoma
• Head and neck cancer, prostate cancer, and ovarian cancer

Research here often explores whether newer treatment strategies can improve survival, deepen remission, or support patients before and after stem cell transplantation.

The site also conducts clinical trials in immune-mediated and autoimmune diseases, aiming to better control chronic inflammation and reduce disease flares. These studies are designed to evaluate treatment benefit, safety, and long-term disease control in conditions that can strongly affect daily life.

• Crohn’s disease and ulcerative colitis
• Systemic lupus erythematosus, lupus nephritis, and systemic sclerosis
• Rheumatoid arthritis, myasthenia gravis, and immune thrombocytopenia
• Myelofibrosis and other inflammatory hematologic disorders

Several projects aim to improve symptom control and identify better ways to match patients with the most effective immunomodulatory therapies.

Clinical research in neurology at the University Hospital Jena KöR covers both neurodegenerative and inflammatory conditions, with a strong emphasis on improving function, slowing progression, and easing symptoms. The trials examine new treatment options and better ways to measure neurological outcomes.

• Multiple sclerosis and secondary progressive multiple sclerosis
• Amyotrophic lateral sclerosis
• Epilepsy, including Dravet syndrome and generalized seizure disorders
• Alzheimer’s disease and other cognitive disorders

This portfolio reflects a broad effort to test therapies that may preserve neurological function, improve quality of life, and support earlier intervention in progressive disease.

Another important research area combines cardiovascular disease and kidney disease, with trials focused on prevention, complication reduction, and better long-term outcomes. These studies often address patients with overlapping heart, vascular, and renal conditions.

• Heart failure, atrial fibrillation, and myocardial infarction
• Atherosclerotic cardiovascular disease and hypercholesterolemia
• Chronic kidney disease, acute kidney injury, and IgA nephropathy
• Hypertrophic cardiomyopathy and cardiorenal complications

The research includes evaluation of new approaches to reduce hospitalization, protect kidney function, and improve management of high-risk cardiovascular patients.

The hospital’s ear, nose, and throat department contributes to trials in otorhinolaryngologic diseases, while related studies also address respiratory and infectious conditions. The research aims to improve diagnosis, symptom relief, and treatment effectiveness across common and complex disorders.

• Chronic rhinosinusitis and nasal polyps
• Sensorineural hearing loss
• Asthma, bronchiectasis, and cystic fibrosis
• Staphylococcus aureus bacteremia, sepsis, and other serious infections

These studies reflect a strong interest in improving care for patients with chronic airway disease, hearing disorders, and infection-related complications.

Research in gastroenterology and hepatology includes inflammatory bowel disease, liver failure, and transplant-related conditions. The trials are designed to test better treatments, support recovery, and improve outcomes in patients with advanced digestive and liver disorders.

• Crohn’s disease and ulcerative colitis
• Acute-on-chronic liver failure, cirrhosis, and hepatorenal syndrome
• Liver transplantation and graft-versus-host disease
• Gastrectomy-related recovery and esophagogastric cancer

Several studies focus on improving digestive disease management, supporting transplant patients, and evaluating strategies that may enhance quality of life after major surgery.

The site also participates in trials for children and adolescents with rare and complex diseases, including cancers, genetic disorders, and immune conditions. These studies aim to improve survival, reduce treatment burden, and support more personalized care.

• Neuroblastoma, Ewing sarcoma, and atypical teratoid/rhabdoid tumor
• Pediatric leukemia and pediatric lymphoma
• Congenital and hereditary disorders such as FNAIT
• Cystic fibrosis and other rare chronic diseases

This research highlights a commitment to advancing care for younger patients with high-need rare conditions, where new treatment options can make a major difference.